Walsall fell to their second successive defeat after Leyton Orient came from behind to win at the Breyer Group Stadium.
Stuart Sinclair scored his second goal for the Saddlers to give them a first half lead but second half goals from Joe Widdowson, Matt Harrold and Conor Wilkinson sealed victory for the O’s.
Darrell Clarke made three changes to the team that lost to Salford City.
Rory Gaffney, Danny Guthrie and Liam Kinsella came into the team in place of Josh Gordon, Elijah Adebayo and Mat Sadler.
Despite a lively start, neither keeper was tested in the opening 15 minutes.
Wes McDonald looked bright for the Saddlers down the left but the first chance fell to the home side when Josh Wright bent a free-kick into the side-netting.
It was the Saddlers who struck first though on 21 minutes when Jules’ low cross caused mayhem in the Orient area and Sinclair pounced to stab the ball home.
Clarke’s men looked dangerous on the counter attack. Dan Scarr and James Clarke had chances before the break as Walsall looked to double their advantage.
Orient made a strong start to the second half and drew level just three minutes into it when the ball was cleared out to Joe Widdowson who fired in a beauty from 25-yards.
The Saddlers settled down and had a spell of possession but Orient came strong again. Dan Happe had a header saved by Liam Roberts on 58 minutes. Two minutes later, they took the lead after a miscommunication in the Walsall defence saw Craig Clay break free and square it to Matt Harrold who tucked the ball past Roberts.
It got worse for the Saddlers 15 minutes later when Conor Wilkinson’s shot took a deflection and found the back of the net.
Orient were dealt a blow 10 minutes from time when Wilkinson was given his marching orders after he grabbed Dan Scarr by the throat.
Despite dominating the possession in the closing stages, the Saddlers failed to capitalise on their one-man advantage.
Roberts (GK); Clarke, Liddle, Scarr, Sadler, Jules; Kinsella, Sinclair; Holden (Adebayo), Guthrie (Norman), McDonald (Gordon); Gaffney.
Subs: Rose (GK), Sadler, Hardy, Bates.